9817_FusoPortal_Gene_996

Protein

9817_FusoPortal_Gene_996

Length

330 amino acids

Protein family membership

Aminoacyl-tRNA synthetase, class Ic (IPR002305)
- Tryptophan-tRNA ligase (IPR002306)
  - Tryptophan-tRNA ligase, bacterial-type (IPR024109)

Homologous superfamilies

Homologous superfamily
1 - 202
Rossmann-like alpha/beta/alpha sandwich fold (IPR014729)

1 50 100 150 200 250 300 330

Domains and repeats

None predicted.

Detailed signature matches

IPR014729

Rossmann-like alpha/beta/alpha sandwich fold
1. G3DSA:3.40.50...
  
  1 - 202
  
  GENE3D
  G3DSA:3.40.50.620 (G3DSA:3.40.50.620)
IPR002305

Aminoacyl-tRNA synthetase, class Ic
1. PF00579 (tRNA-synt_1b)
  
  4 - 277
  
  Pfam
  PF00579 (tRNA-synt_1b)
IPR002306

Tryptophan-tRNA ligase
1. cd00806 (TrpRS_core)
  
  3 - 276
  
  CDD
  cd00806 (TrpRS_core)
2. PR01039 (TRNASYNTHTRP)
  
  14 - 30
  
  PRINTS
  PR01039 (TRNASYNTHTRP)
  
  66 - 85
  
  PRINTS
  PR01039 (TRNASYNTHTRP)
  
  141 - 162
  
  PRINTS
  PR01039 (TRNASYNTHTRP)
  
  193 - 203
  
  PRINTS
  PR01039 (TRNASYNTHTRP)
3. TIGR00233
  
  2 - 322
  
  TIGRFAMs
  TIGR00233 (TIGR00233)
IPR024109

Tryptophan-tRNA ligase, bacterial-type
1. MF_00140_B (Trp_tRN...)
  
  1 - 323
  
  HAMAP
  MF_00140_B (Trp_tRNA_synth_B)
IPR001412

Aminoacyl-tRNA synthetase, class I, conserved site
1. PS00178 (AA_TRNA_LI...)
  
  10 - 19
  
  PROSITE patterns
  PS00178 (AA_TRNA_LIGASE_I)

no IPR

Unintegrated signatures

G3DSA:1.10.24...

203 - 290

GENE3D
G3DSA:1.10.240.10 (G3DSA:1.10.240.10)
PTHR43766 (FAMILY N...)

2 - 322

PANTHER
PTHR43766 (FAMILY NOT NAMED)
SSF52374 (Nucleotid...)

2 - 322

SUPERFAMILY
SSF52374 (Nucleotidylyl transferase)

Residue annotation

active site cd00806

5L

active site
5L, 6S, 7G, 8I, 9Q, 15H, 17G, 18N, 21G, 40F, 45H, 82Q, 127Y, 131M, 134D, 143V, 145V, 146G, 148D, 149Q, 152H, 184A, 193K, 194M, 196K
CDD
cd00806 (TrpRS_core)

6S

active site
5L, 6S, 7G, 8I, 9Q, 15H, 17G, 18N, 21G, 40F, 45H, 82Q, 127Y, 131M, 134D, 143V, 145V, 146G, 148D, 149Q, 152H, 184A, 193K, 194M, 196K
CDD
cd00806 (TrpRS_core)

7G

active site
5L, 6S, 7G, 8I, 9Q, 15H, 17G, 18N, 21G, 40F, 45H, 82Q, 127Y, 131M, 134D, 143V, 145V, 146G, 148D, 149Q, 152H, 184A, 193K, 194M, 196K
CDD
cd00806 (TrpRS_core)

8I

active site
5L, 6S, 7G, 8I, 9Q, 15H, 17G, 18N, 21G, 40F, 45H, 82Q, 127Y, 131M, 134D, 143V, 145V, 146G, 148D, 149Q, 152H, 184A, 193K, 194M, 196K
CDD
cd00806 (TrpRS_core)

9Q

active site
5L, 6S, 7G, 8I, 9Q, 15H, 17G, 18N, 21G, 40F, 45H, 82Q, 127Y, 131M, 134D, 143V, 145V, 146G, 148D, 149Q, 152H, 184A, 193K, 194M, 196K
CDD
cd00806 (TrpRS_core)

15H

active site
5L, 6S, 7G, 8I, 9Q, 15H, 17G, 18N, 21G, 40F, 45H, 82Q, 127Y, 131M, 134D, 143V, 145V, 146G, 148D, 149Q, 152H, 184A, 193K, 194M, 196K
CDD
cd00806 (TrpRS_core)

17G

active site
5L, 6S, 7G, 8I, 9Q, 15H, 17G, 18N, 21G, 40F, 45H, 82Q, 127Y, 131M, 134D, 143V, 145V, 146G, 148D, 149Q, 152H, 184A, 193K, 194M, 196K
CDD
cd00806 (TrpRS_core)

18N

active site
5L, 6S, 7G, 8I, 9Q, 15H, 17G, 18N, 21G, 40F, 45H, 82Q, 127Y, 131M, 134D, 143V, 145V, 146G, 148D, 149Q, 152H, 184A, 193K, 194M, 196K
CDD
cd00806 (TrpRS_core)

21G

active site
5L, 6S, 7G, 8I, 9Q, 15H, 17G, 18N, 21G, 40F, 45H, 82Q, 127Y, 131M, 134D, 143V, 145V, 146G, 148D, 149Q, 152H, 184A, 193K, 194M, 196K
CDD
cd00806 (TrpRS_core)

40F

active site
5L, 6S, 7G, 8I, 9Q, 15H, 17G, 18N, 21G, 40F, 45H, 82Q, 127Y, 131M, 134D, 143V, 145V, 146G, 148D, 149Q, 152H, 184A, 193K, 194M, 196K
CDD
cd00806 (TrpRS_core)

45H

active site
5L, 6S, 7G, 8I, 9Q, 15H, 17G, 18N, 21G, 40F, 45H, 82Q, 127Y, 131M, 134D, 143V, 145V, 146G, 148D, 149Q, 152H, 184A, 193K, 194M, 196K
CDD
cd00806 (TrpRS_core)

82Q

active site
5L, 6S, 7G, 8I, 9Q, 15H, 17G, 18N, 21G, 40F, 45H, 82Q, 127Y, 131M, 134D, 143V, 145V, 146G, 148D, 149Q, 152H, 184A, 193K, 194M, 196K
CDD
cd00806 (TrpRS_core)

127Y

active site
5L, 6S, 7G, 8I, 9Q, 15H, 17G, 18N, 21G, 40F, 45H, 82Q, 127Y, 131M, 134D, 143V, 145V, 146G, 148D, 149Q, 152H, 184A, 193K, 194M, 196K
CDD
cd00806 (TrpRS_core)

131M

active site
5L, 6S, 7G, 8I, 9Q, 15H, 17G, 18N, 21G, 40F, 45H, 82Q, 127Y, 131M, 134D, 143V, 145V, 146G, 148D, 149Q, 152H, 184A, 193K, 194M, 196K
CDD
cd00806 (TrpRS_core)

134D

active site
5L, 6S, 7G, 8I, 9Q, 15H, 17G, 18N, 21G, 40F, 45H, 82Q, 127Y, 131M, 134D, 143V, 145V, 146G, 148D, 149Q, 152H, 184A, 193K, 194M, 196K
CDD
cd00806 (TrpRS_core)

143V

active site
5L, 6S, 7G, 8I, 9Q, 15H, 17G, 18N, 21G, 40F, 45H, 82Q, 127Y, 131M, 134D, 143V, 145V, 146G, 148D, 149Q, 152H, 184A, 193K, 194M, 196K
CDD
cd00806 (TrpRS_core)

145V

active site
5L, 6S, 7G, 8I, 9Q, 15H, 17G, 18N, 21G, 40F, 45H, 82Q, 127Y, 131M, 134D, 143V, 145V, 146G, 148D, 149Q, 152H, 184A, 193K, 194M, 196K
CDD
cd00806 (TrpRS_core)

146G

active site
5L, 6S, 7G, 8I, 9Q, 15H, 17G, 18N, 21G, 40F, 45H, 82Q, 127Y, 131M, 134D, 143V, 145V, 146G, 148D, 149Q, 152H, 184A, 193K, 194M, 196K
CDD
cd00806 (TrpRS_core)

148D

active site
5L, 6S, 7G, 8I, 9Q, 15H, 17G, 18N, 21G, 40F, 45H, 82Q, 127Y, 131M, 134D, 143V, 145V, 146G, 148D, 149Q, 152H, 184A, 193K, 194M, 196K
CDD
cd00806 (TrpRS_core)

149Q

active site
5L, 6S, 7G, 8I, 9Q, 15H, 17G, 18N, 21G, 40F, 45H, 82Q, 127Y, 131M, 134D, 143V, 145V, 146G, 148D, 149Q, 152H, 184A, 193K, 194M, 196K
CDD
cd00806 (TrpRS_core)

152H

active site
5L, 6S, 7G, 8I, 9Q, 15H, 17G, 18N, 21G, 40F, 45H, 82Q, 127Y, 131M, 134D, 143V, 145V, 146G, 148D, 149Q, 152H, 184A, 193K, 194M, 196K
CDD
cd00806 (TrpRS_core)

184A

active site
5L, 6S, 7G, 8I, 9Q, 15H, 17G, 18N, 21G, 40F, 45H, 82Q, 127Y, 131M, 134D, 143V, 145V, 146G, 148D, 149Q, 152H, 184A, 193K, 194M, 196K
CDD
cd00806 (TrpRS_core)

193K

active site
5L, 6S, 7G, 8I, 9Q, 15H, 17G, 18N, 21G, 40F, 45H, 82Q, 127Y, 131M, 134D, 143V, 145V, 146G, 148D, 149Q, 152H, 184A, 193K, 194M, 196K
CDD
cd00806 (TrpRS_core)

194M

active site
5L, 6S, 7G, 8I, 9Q, 15H, 17G, 18N, 21G, 40F, 45H, 82Q, 127Y, 131M, 134D, 143V, 145V, 146G, 148D, 149Q, 152H, 184A, 193K, 194M, 196K
CDD
cd00806 (TrpRS_core)

196K

active site
5L, 6S, 7G, 8I, 9Q, 15H, 17G, 18N, 21G, 40F, 45H, 82Q, 127Y, 131M, 134D, 143V, 145V, 146G, 148D, 149Q, 152H, 184A, 193K, 194M, 196K
CDD
cd00806 (TrpRS_core)
HIGH motif cd00806

15H

HIGH motif
15H, 16L, 17G, 18N
CDD
cd00806 (TrpRS_core)

16L

HIGH motif
15H, 16L, 17G, 18N
CDD
cd00806 (TrpRS_core)

17G

HIGH motif
15H, 16L, 17G, 18N
CDD
cd00806 (TrpRS_core)

18N

HIGH motif
15H, 16L, 17G, 18N
CDD
cd00806 (TrpRS_core)
dimer interface cd...

44Y

dimer interface
44Y, 47L, 48T, 88H, 89V, 91L, 92S, 93W, 96S, 97N, 99T, 100P, 101V, 102G, 104L, 105E, 123G, 125L, 126T, 129V, 130L
CDD
cd00806 (TrpRS_core)

47L

dimer interface
44Y, 47L, 48T, 88H, 89V, 91L, 92S, 93W, 96S, 97N, 99T, 100P, 101V, 102G, 104L, 105E, 123G, 125L, 126T, 129V, 130L
CDD
cd00806 (TrpRS_core)

48T

dimer interface
44Y, 47L, 48T, 88H, 89V, 91L, 92S, 93W, 96S, 97N, 99T, 100P, 101V, 102G, 104L, 105E, 123G, 125L, 126T, 129V, 130L
CDD
cd00806 (TrpRS_core)

88H

dimer interface
44Y, 47L, 48T, 88H, 89V, 91L, 92S, 93W, 96S, 97N, 99T, 100P, 101V, 102G, 104L, 105E, 123G, 125L, 126T, 129V, 130L
CDD
cd00806 (TrpRS_core)

89V

dimer interface
44Y, 47L, 48T, 88H, 89V, 91L, 92S, 93W, 96S, 97N, 99T, 100P, 101V, 102G, 104L, 105E, 123G, 125L, 126T, 129V, 130L
CDD
cd00806 (TrpRS_core)

91L

dimer interface
44Y, 47L, 48T, 88H, 89V, 91L, 92S, 93W, 96S, 97N, 99T, 100P, 101V, 102G, 104L, 105E, 123G, 125L, 126T, 129V, 130L
CDD
cd00806 (TrpRS_core)

92S

dimer interface
44Y, 47L, 48T, 88H, 89V, 91L, 92S, 93W, 96S, 97N, 99T, 100P, 101V, 102G, 104L, 105E, 123G, 125L, 126T, 129V, 130L
CDD
cd00806 (TrpRS_core)

93W

dimer interface
44Y, 47L, 48T, 88H, 89V, 91L, 92S, 93W, 96S, 97N, 99T, 100P, 101V, 102G, 104L, 105E, 123G, 125L, 126T, 129V, 130L
CDD
cd00806 (TrpRS_core)

96S

dimer interface
44Y, 47L, 48T, 88H, 89V, 91L, 92S, 93W, 96S, 97N, 99T, 100P, 101V, 102G, 104L, 105E, 123G, 125L, 126T, 129V, 130L
CDD
cd00806 (TrpRS_core)

97N

dimer interface
44Y, 47L, 48T, 88H, 89V, 91L, 92S, 93W, 96S, 97N, 99T, 100P, 101V, 102G, 104L, 105E, 123G, 125L, 126T, 129V, 130L
CDD
cd00806 (TrpRS_core)

99T

dimer interface
44Y, 47L, 48T, 88H, 89V, 91L, 92S, 93W, 96S, 97N, 99T, 100P, 101V, 102G, 104L, 105E, 123G, 125L, 126T, 129V, 130L
CDD
cd00806 (TrpRS_core)

100P

dimer interface
44Y, 47L, 48T, 88H, 89V, 91L, 92S, 93W, 96S, 97N, 99T, 100P, 101V, 102G, 104L, 105E, 123G, 125L, 126T, 129V, 130L
CDD
cd00806 (TrpRS_core)

101V

dimer interface
44Y, 47L, 48T, 88H, 89V, 91L, 92S, 93W, 96S, 97N, 99T, 100P, 101V, 102G, 104L, 105E, 123G, 125L, 126T, 129V, 130L
CDD
cd00806 (TrpRS_core)

102G

dimer interface
44Y, 47L, 48T, 88H, 89V, 91L, 92S, 93W, 96S, 97N, 99T, 100P, 101V, 102G, 104L, 105E, 123G, 125L, 126T, 129V, 130L
CDD
cd00806 (TrpRS_core)

104L

dimer interface
44Y, 47L, 48T, 88H, 89V, 91L, 92S, 93W, 96S, 97N, 99T, 100P, 101V, 102G, 104L, 105E, 123G, 125L, 126T, 129V, 130L
CDD
cd00806 (TrpRS_core)

105E

dimer interface
44Y, 47L, 48T, 88H, 89V, 91L, 92S, 93W, 96S, 97N, 99T, 100P, 101V, 102G, 104L, 105E, 123G, 125L, 126T, 129V, 130L
CDD
cd00806 (TrpRS_core)

123G

dimer interface
44Y, 47L, 48T, 88H, 89V, 91L, 92S, 93W, 96S, 97N, 99T, 100P, 101V, 102G, 104L, 105E, 123G, 125L, 126T, 129V, 130L
CDD
cd00806 (TrpRS_core)

125L

dimer interface
44Y, 47L, 48T, 88H, 89V, 91L, 92S, 93W, 96S, 97N, 99T, 100P, 101V, 102G, 104L, 105E, 123G, 125L, 126T, 129V, 130L
CDD
cd00806 (TrpRS_core)

126T

dimer interface
44Y, 47L, 48T, 88H, 89V, 91L, 92S, 93W, 96S, 97N, 99T, 100P, 101V, 102G, 104L, 105E, 123G, 125L, 126T, 129V, 130L
CDD
cd00806 (TrpRS_core)

129V

dimer interface
44Y, 47L, 48T, 88H, 89V, 91L, 92S, 93W, 96S, 97N, 99T, 100P, 101V, 102G, 104L, 105E, 123G, 125L, 126T, 129V, 130L
CDD
cd00806 (TrpRS_core)

130L

dimer interface
44Y, 47L, 48T, 88H, 89V, 91L, 92S, 93W, 96S, 97N, 99T, 100P, 101V, 102G, 104L, 105E, 123G, 125L, 126T, 129V, 130L
CDD
cd00806 (TrpRS_core)
KMSKS motif cd00806

193K

KMSKS motif
193K, 194M, 195S, 196K, 197S
CDD
cd00806 (TrpRS_core)

194M

KMSKS motif
193K, 194M, 195S, 196K, 197S
CDD
cd00806 (TrpRS_core)

195S

KMSKS motif
193K, 194M, 195S, 196K, 197S
CDD
cd00806 (TrpRS_core)

196K

KMSKS motif
193K, 194M, 195S, 196K, 197S
CDD
cd00806 (TrpRS_core)

197S

KMSKS motif
193K, 194M, 195S, 196K, 197S
CDD
cd00806 (TrpRS_core)

GO term prediction

Biological Process

GO:0006418 tRNA aminoacylation for protein translation
GO:0006436 tryptophanyl-tRNA aminoacylation

Molecular Function

GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004830 tryptophan-tRNA ligase activity
GO:0005524 ATP binding

Cellular Component

GO:0005737 cytoplasm

Filter view on

Entry type

Status

Per-residue features

9817_FusoPortal_Gene_996

Protein family membership

Homologous superfamilies

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component